The R&D Dept.: Local patents for 11.2.16

Neutralizing GP41 antibodies and their use
Patent No. 9,475,862
Monoclonal neutralizing antibodies are disclosed that specifically bind to the HIV-1 gp41 membrane-proximal external region (MPER). Also disclosed are compositions including the disclosed antibodies that specifically bind gp41, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of HIV-1 in a biological sample, or detecting an HIV-1 infection or diagnosing AIDS in a subject. In additional, the broad neutralization breadth of the disclosed antibodies makes them ideal for treating a subject with an HIV infection. Thus, disclosed are methods of treating and/or preventing HIV infection.
Inventors: Mark Connors (Bethesda, Md.), Jinghe Huang (Bethesda, Md.), Leo B. Laub (Richmond), Peter Kwong (Washington, D.C.), Gary Nabel (Cambridge, Mass.), John R. Mascola (Rockville, Md.), Baoshan Zhang (Bethesda, Md.), Rebecca S. Rudicell (Silver Springs, Md.), Ivelin Georgiev (Gaithersburg, Md.), Yongping Yang (Potomac, Md.), Jiang Zhu (Ashburn, Va.), Gilad Ofek (Washington, D.C.)
Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, D.C.)
Oct. 25, 2016

Carton and carton blank
Patent No. 9,475,606
A carton (90) for packaging one of more articles includes a first panel (22a, 26a, 128a, 226a) and a second panel (24a, 28a, 124a, 222a). The first panel (22a, 26a, 128a, 226a) is in at least partially overlapping relationship with the second panel (24a, 28a, 124a, 222a) to define an overlapping region. The carton (90) includes a weakened line of severance (30a, 30b, 34a, 34b, 49a, 49b, 69a, 69b, 129a, 129b, 229a, 229b) which extends from the first panel across the overlapping region and into the second panel to be contiguous. The first panel includes a recess (R) defined at least in part in the overlapping region and extending at least partially across a portion of the first panel in the overlapping region. The recess (R) is arranged in registry with at least a portion of the weakened line of severance in the second panel.
Inventors: Nathaniel B. Ball (Richmond), Andrew T. Peeler (Henrico, Va.), Bradford J. Walling (Chesterfield, Va.), Matthew E. Zacherle (Chesterfield, Va.), Caleb S. Loftin (Richmond)
Assignee: WestRock Packaging Systems (Norcross, Ga.)
Oct. 25, 2016

3D tracking of an HDR source using a flat panel detector
Patent No. 9,474,493
A method and apparatus are used to compare in real-time an intended radiation treatment plan with a delivered plan. Markers are arranged, on a subject receiving radiation, at three-dimensional (3D) positions between a two dimensional radiation detector and a radiation source and are used to reconstruct the actual position of a high dose rate (HDR) source in three-dimensional (3D) space. The detected position is compared with the intended radiation path of the treatment plan. Adjustments can be made to the treatment plan if the detected position and the intended path do not correspond.
Inventors: Dorin A. Todor (Richmond), Aditya A. Bondal (Madison, Wisc.)
Assignee: Virginia Commonwealth University (Richmond)
Oct. 25, 2016

Automated mix in-cup apparatus
Patent No. 9,474,417
An automated mix in-cup apparatus includes a frame having a cup-holder to secure a tapered cup selectively placed therein, and a first motor operatively connected to the cup-holder to rotate the cup-holder. A reciprocating carriage is axially supported by the frame and supports a second motor and a rotatable mixing blade to mix a consumable material. The mixing blade is secured to a shaft axially extending from the second motor, the shaft defining a longitudinal axis and the second motor configured to rotate the shaft and the mixing blade. Reciprocal movement of the carriage axially translates the mixing blade into and out of the tapered cup in the cup-holder. The cup-holder and the first motor are oriented at an incline, defining a tilt angle relative to the longitudinal axis of the shaft, whereby the shaft and the rotatable blade are positioned off-center relative to the tapered cup in the cup-holder.
Inventors: Ernest B. Pryor Jr. (Maidens, Va.), Benjamin H. Branson III (Mechanicsville, Va.), Brian P. Williams (Midlothian, Va.), James Robert Gaynor (Richmond)
Assignee: Hamilton Beach Brands Inc. (Glen Allen, Va.)
Oct. 25, 2016

Kitchen appliance and method of using same
Patent No. 9,474,410
A kitchen appliance includes a housing that defines a cavity. The housing has a housing rim defining an opening to the cavity. A heating or cooling element is disposed within the housing to heat or cool the cavity. A container has a generally hollow interior and a container rim. A lid is sized and shaped to at least partially cover the opening of the container when placed on the container. The lid has an exterior surface and an opposing interior surface. At least one latching mechanism or handle is operable to seal the contents of the appliance within the appliance.
Inventors: Arthur W. Hudgins (Henrico, Va.), Mark C. Steiner (Midlothian, Va.), Ernest B. Pryor Jr. (Maidens, Va.), Martin Brady (Manakin Sabot, Va.), Yvonne Olson (Richmond), Alexander D. Raring (Midlothian, Va.), Guoyao Ye (Glen Allen, Va.), John D. Barnes (Richmond), Michael G. Sandford (Mechanicsville, Va.), George Stamper (Quinton, Va.), Patrick T. Mulvaney (Richmond), Michael Garman (Moseley, Va.)
Assignee: Hamilton Beach Brands Inc. (Glen Allen, Va.)
Oct. 25, 2016

Electronic cigarette
Patent No. 9,474,306
An electronic smoking article includes a liquid supply including liquid material, a heater operable to heat the liquid material to a temperature sufficient to vaporize the liquid material and form an aerosol, a wick in communication with the liquid material and in communication with the heater such that the wick delivers the liquid material to the heater, at least one air inlet operable to deliver air to a central air passage upstream of the heater, and a mouth end insert having at least two diverging outlets.
Inventors: Christopher S. Tucker (Midlothian, Va.), Geoffrey B. Jordan (Midlothian, Va.), Barry S. Smith (Hopewell, Va.), Ali A. Rostami (Richmond)
Assignee: Altria Client Services (Richmond)
Oct. 25, 2016

Hummingbird feeder
Patent No. 9,474,253
A hummingbird feeder that includes a flower petal shaped attractive structure attached to the hollow body of the feeder around a feeding hole and a removable, replaceable, and non-bulky feeding tube designed to be removably placed within the feeding hole.
Inventors: Janice M. Coughlin (Charlottesville, Va.), Tere Eggleston (Richmond)
Assignee: Plow & Hearth (Madison, Va.)
Oct. 25, 2016

Method and apparatus for using at least a portion of a one-time password as a dynamic card verification value
Patent No. 9,477,959
Method and apparatus for using at least a portion of a one-time password as a dynamic card verification value (CVV) are disclosed. A credit/debit card is able to generate a dynamic card verification value (CVV). Such a card may also include an indication that the dynamic CVV is to be used as a security code for purchasing or other transactions. A card-based financial transaction can be authorized in accordance with the use of a dynamic CVV by receiving a transaction authorization request for a specific credit/debit card, wherein the transaction authorization request includes a dynamic CVV. The dynamic CVV can be compared to at least a portion of a one-time password generated for the specific credit/debit card, and a transaction authorization can be sent to the merchant or vendor when the dynamic CVV matches all or a portion of the one-time password.
Inventors: James M. Ashfield (Midlothian, Va.)
Assignee: Bank of America Corp. (Charlotte, N.C.)
Oct. 25, 2016

Carbamates from glycerine carbonate for pearlization
Patent No. 9,474,916
Alkyl and/or alkenyl glycerol carbamate prepared by reacting a carbonate selected from the group consisting of glycerol carbonate, diglycerol carbonate, polyglycerol carbonate and mixtures thereof, with an amine of the general formula (I): HNR.sup.1R.sup.2 (I) wherein R.sup.1 represents a hydrogen atom or a hydrocarbon group selected from the group consisting of alkyl groups and alkenyl groups having from 1 to 22 carbon atoms and R.sup.2 represents a hydrocarbon group selected from the group consisting of alkyl groups and alkenyl groups having from 4 to 22 carbon atoms, and cyclic alkyl groups having 5 or 6 carbon atoms, are described along with methods for their use as pearlizing agents in surface-active preparations.
Inventors: Bin Gu (State College, Penn.), Brajesh Jha (Midlothian, Va.), Sithamalli Chandramouli (Madison, Wisc.), Jie Yang (Madison, Wisc.)
Assignee: Evonik Degussa GmbH (Essen, Germany)
Oct. 25, 2016

Intravascular arterial to venous anastomosis and tissue welding catheter
Patent No. 9,474,562
A catheter-based device tracks over a guidewire which has been placed from a first blood vessel into a second blood vessel. The distal tip of the catheter is advanced into the second vessel while a proximal member remains in the first vessel. Matching blunt tapered surfaces on each of the distal tip and the proximal member are clamped together, with adjacent walls of each vessel between them, after which a known, controlled pressure is applied between the two surfaces. Heat energy is then applied to the blunt surfaces for approximately 1-30 seconds to weld the walls of the two vessels together. After coaptation of the vessel walls, the heat is increased to then cut through the vessel walls to create a fistula of the desired size.
Inventors: Brad M. Kellerman (Escondido, Calif.), David Trottingwolf Aldridge (Laguna Hills, Calif.), David K. Wrolstad (Yucaipa, Calif.), Mark A. Ritchart (Murrieta, Calif.), Jeffrey E. Hull (Midlothian, Va.), Gene Reu (San Juan Capistrano, Calif.)
Assignee: Avenu Medical Inc. (San Juan Capistrano, Calif.)
Oct. 25, 2016

Kitchen appliance with an improved temperature probe jack receiver cover
Patent No. 9,474,413
A jack receiver for a kitchen cooking appliance includes a bracket mounted to the appliance. The bracket includes an aperture for receiving a thermometer therethrough. A jack socket for receiving and engaging a portion of the thermometer therein projects from the bracket aperture to an opposing side of the chamber’s wall from the jack receiver, and is in operative communication with the appliance’s controller. A cover is pivotably attached to the bracket and a biasing member exerts a biasing force onto the cover to bias the cover into a position covering the bracket aperture. The cover is pivotable against the biasing force of the biasing member, uncovering the bracket aperture, for insertion of the thermometer. Removal of the thermometer from the jack receiver permits automatic pivotable return of the cover to the covering position under the biasing force of the biasing member.
Inventors: Mark K. Romandy (Midlothian, Va.)
Assignee: Hamilton Beach Brands Inc. (Glen Allen, Va.)
Oct. 25, 2016

Medicament delivery device for administration of opioid antagonists including formulations for naloxone
Patent No. 9,474,869
Medicament delivery devices for administration of opioid antagonists are described herein. In some embodiments, an apparatus includes a housing, a medicament container disposed within the housing and an energy storage member disposed within the housing. The medicament container is filled with a naloxone composition that includes naloxone or salts thereof, a tonicity-adjusting agent, and a pH adjusting agent, whereby the osmolality of the naloxone composition ranges from about 250-350 mOsm and the pH ranges from about 3-5. The energy storage member is configured to produce a force to deliver the naloxone composition.
Inventors: Eric S. Edwards (Moseley, Va.), Evan T. Edwards (Charlottesville, Va.), Mark J. Licata (Doswell, Va.), Frank E. Blondino (Henrico, Va.)
Assignee: kaleo Inc. (Richmond)
Oct. 25, 2016

Safety syringe and methods for administration of a medicament dose by subject weight
Patent No. 9,474,864
An apparatus includes a syringe body and a plunger. The syringe body defines a volume configured to contain a medicament. A proximal end portion of the syringe body includes an engagement portion, and a distal end portion of the syringe body includes a delivery tip. A side wall of the syringe body includes a transparent window. The plunger has a distal end portion configured to move within the volume of the syringe body to convey the medicament. An engagement portion of the plunger is configured to interface with the engagement portion of the syringe body to limit rotation of the plunger about a longitudinal axis of the plunger. An outer surface of the plunger includes a series of indicia, at least one which is visible through the transparent window.
Inventors: Jeffrey M. Leary (Henrico, Va.)
Assignee: Brell Medical Innovations (Henrico, Va.)
Oct. 25, 2016

Copolymer fibers and yarns and processes for making same
Patent No. 9,481,946
The present invention concerns methods for obtaining high-tenacity aramid yarn, wherein the yarn is made of a copolymer obtained from a mixture of monomers comprising 5-(6)-amino-2-(p-aminophenyl)benzimidazole, an aromatic para-diamine, and an aromatic para-diacid. The method comprises: a) spinning said copolymer from an inorganic acid solvent to produce the aramid yarn; b) washing the yarn with a basic aqueous solution for at least 5 seconds; and c) heating the yarn; wherein the yarn is heated in at least two process steps, comprising (i) in a first step the yarn is heated at a temperature of 200 to 360.degree. C. at a tension of at least 0.2 cN/dtex, followed by (ii) a second step wherein the yarn is heated at a temperature of 370 to 500.degree. C. at a tension of less than 1 cN/dtex.
Inventors: Warren Francis Knoff (Richmond), Christopher William Newton (Richmond)
Assignee: E I Du Pont De Nemours and Co. (Wilmington, Del.)
Nov. 1, 2016

Thiophosphates and thiophosphate derivatives as lubricant additives
Patent No. 9,481,696
The present invention provides thiophosphates and thiophosphate derivatives useful as antiwear additive components, lubricant additive compositions and lubricant compositions each comprising such compounds, and methods for making and using the same. In one aspect, the invention relates to a compound of formula (I): ##STR00001## or a tribologically acceptable salt thereof.
Inventors: David Edwards (Richmond), Kristine Durbin (Mechanicsville, Va.), Robert E. McCovick (Chesterfield, Va.)
Assignee: Afton Chemical Corp. (Richmond)
Nov. 1, 2016

Child-resistant closure systems for containers
Patent No. 9,480,802
A child-resistant closure system for a pump sprayer comprises a cap, a dispensing tip configured to receive the cap thereon, and a base secured to the dispensing tip and secured to a dispenser bottle. The tip has a slot defined therein that comprises a wider insertion/removal portion for inserting or removing a downwardly extending leg and a narrower locking portion for engaging the leg to lock the cap to the dispensing tip. The cap is selectively secured to the dispensing dip by rotating the cap such that the leg moves from the wider portion of the slot to the narrower portion of the slot, such that the narrower portion of the slot engages leg. The leg extends downward through the slot to contact the top of the base so as to allow for the sprayer pump unit to be locked out from operation.
Inventors: Launce R. Barber (Richmond), Thomas J. A. Zuber (Fort Lee, N.J.), Corey R. Vaughan (Seattle, Wash.)
Assignee: Taptango (Gainesville, Va.)
Nov. 1, 2016

Sulfated-oxysterol and oxysterol sulfation by hydroxysterol sulfotransferase promote lipid homeostasis and liver proliferation
Patent No. 9,480,692
Methods and compositions for the prevention and treatment of liver damage or disease in a subject in need thereof are provided. The methods involve providing the sulfated oxysterol 25-hydroxycholesterol-3-sulfate (25HC3S) to the subject e.g. by 1) administering 25HC3S to the subject; or 2) overexpressing, in the subject, the hydroxysterol sulfotransferase enzyme SULT2B1b, which catalyzes the sulfation of 25-hydroxycholesterol (25HC) to form 25HC3S.
Inventors: Shunlin Ren (Richmond)
Assignee: Virginia Commonwealth University (Richmond)
Nov. 1, 2016

Segmentation and fracture detection in CT images
Patent No. 9,480,439
Provided is a new hierarchical methodology having a series of computational steps such as adaptive window creation, 2-D SWT application, masking, and boundary tracing is proposed. The techniques and systems are able to detect and quantify fracture as well as to generate recommendations for decision-making and treatment planning in traumatic pelvic injuries.
Inventors: Jie Wu (Richmond), Rosalyn Hobson Hargraves (Richmond), Kayvan Najarian (Richmond), Ashwin Belle (Richmond), Kevin R. Ward (Ann Arbor, Mich.)
Assignee: Virginia Commonwealth University (Richmond)

Method for measurement of bioavailable testosterone
Patent No. 9,482,678
Provided are methods for determining level of bioactive testosterone in a biological sample. In one aspect, aromatase enzyme is utilized to convert free, bio-available testosterone into estradiol and the amount of estradiol is measured before and after the addition of enzyme. The difference in measurements provides the amount of bioactive testosterone in the sample. In another aspect, a competitor of testosterone binding to SHBG is utilized to displace testosterone bound to SHBG. Measurements of total testosterone in the sample before addition of competitor and afterwards are taken, such that the delta reflects the amount of testosterone that was bound on SHBG.
Inventors:  Rebecca Caffrey (Chesterfield, Va.)
Assignee:  N/A
Nov. 1, 2016

Feed device for linear airflow separator
Patent No. 9,480,282
A feed device for a linear airflow separator that eliminates the use of a winnower in the separation of tobacco products. The feed device includes an adjustable angle baffle deflector in combination with an air knife. The air-fed adjustable angle baffle deflector feeds with non-product contact and as a result does not lead to mechanical degradation of the treated material. The air knife is fed with air from a high pressure blower having a variable frequency drive. The feed device treats the product with air only, thereby eliminating mechanical contact with the product and resulting in higher separation yields and higher operating efficiency than conventional recirculating pneumatic separators.
Inventors: Sam Levy (Chesterfield, Va.)
Assignee: Evans MacTavish Agricraft Inc. (Wilson, N.C.)
Nov. 1, 2016

Food processor with multiple processing containers
Patent No. 9,480,365
A food processor includes a housing, a motor disposed within the housing, an output shaft extending outwardly from the housing, a first processing container, a second processing container, and a lid removably and independently attachable to either one of the first and second processing containers. The first and second processing container are each independently and removably attachable to the housing. The first processing container is configured to be at least partially removably disposed within the interior of the second processing container. The lid is attached to the first processing container and the first processing container is attached to the housing in a first operating position. The lid is attached to the second processing container and the second processing container is attached to the housing in a second operating positi on. A portion of the first processing container is disposed within the interior of the second processing container in a storage position.
Inventors: Michael W. Allen (Glen Allen, Va.)
Assignee: Hamilton Beach Brands Inc. (Glen Allen, Va.)
Nov. 1, 2016

Assessing user performance in a community of users of data storage resources
Patent No. 9,483,558
According to certain aspects, a method of assessing users of a data storage system can include receiving configuration information relating to a deployed configuration of a first data storage cell and including number of installed data storage hardware and/or software components, the first data storage cell comprising a plurality of client computing devices and being configured to create and store one or more secondary copies of primary data generated by the plurality of client computing devices. The method may also include receiving information relating to an incident opened by a user of the first data storage cell. The method may further include updating a performance metric associated with the user to a new value to reflect a negative impact on the performance metric resulting from the opening of the incident by the user, wherein the degree of the negative impact is based at least in part on the configuration information.
Inventors: Robert Keith Brower Jr. (Midlothian, Va.), Peter John Messore (Manahawkin, N.J.)
Assignee: Commvault Systems Inc. (Tinton Falls, N.J.)
Nov. 1, 2016

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