The R&D Dept.: Local patents for 10.18.17

Preventing propagation of malicious content in a virtual universe

Patent No. 9,785,909

An invention for preventing propagation of malicious content within a virtual universe is provided. In one embodiment, a malicious content propagation prevention tool provides this capability. The malicious content propagation prevention tool includes a scanning component configured to scan a plurality of inventory items within a virtual universe. An identification component is configured to identify a set of malicious inventory from the plurality of inventory items. The malicious content propagation prevention tool further comprises an assurance component configured to prevent propagation of malicious content within the virtual universe by performing at least one of the following: isolating the set of malicious inventory items, and modifying a malicious behavior caused by the set of malicious inventory items.

Inventors:  Rick A. Hamilton II (Richmond), Brian M. O’Connell (Research Triangle Park, N.C.), Clifford A. Pickover (Yorktown Heights, N.Y.), Keith R. Walker (Austin, Texas)

Assignee:  International Business Machines Corp. (Armonk, N.Y.)

Oct. 10, 2017

Compositions comprising C5 and C6 oligosaccharides

Patent No. 9,783,860

Compositions comprising C5 and C6 saccharides of varying degrees of polymerization and low levels of undesirable impurities, such as compounds containing sulfur, nitrogen, or metals, are disclosed.

Inventors:  Daniel Clay Floyd (Richmond), Kiran Kadam (Golden, Colo.), Srinivas Kilambi (Duluth, Ga.)

Assignee:  Renmatix Inc. (King of Prussia, Penn.)

Oct. 10, 2017

Mannich detergents for hydrocarbon fuels

Patent No. 9,783,752

New, highly effective substantially pure Mannich detergents for use in hydrocarbon fuels reduce engine deposits in spark and compression ignition internal combustion engines. The Mannich condensation reaction products are obtainable by reacting: (i) a polyamine having primary amino groups, (ii) a hydrocarbyl-substituted hydroxyaromatic compound, and (iii) an aldehyde, wherein the reaction is conducted at in a molar ratio of (i):(ii):(iii) of approximately 1:2:3. The Mannich detergent compounds may be dispersed in a liquid carrier to provide a fuel additive concentrate for hydrocarbon engine fuels which effectively control engine deposit formation in intake valves, port fuel injectors and combustion chambers.

Inventors:  Dennis J. Malfer (Glen Allen, Va.), May D. Thomas (Richmond)

Assignee:  Afton Chemical Corp. (Richmond)

Oct. 10, 2017

Neutralizing GP41 antibodies and their use

Patent No. 9,783,595

Monoclonal neutralizing antibodies are disclosed that specifically bind to the HIV-1 gp41 membrane-proximal external region (MPER). Also disclosed are compositions including the disclosed antibodies that specifically bind gp41, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of HIV-1 in a biological sample, or detecting an HIV-1 infection or diagnosing AIDS in a subject. In additional, the broad neutralization breadth of the disclosed antibodies makes them ideal for treating a subject with an HIV infection. Thus, disclosed are methods of treating and/or preventing HIV infection.

Inventors:  Mark Connors (Bethesda, Md.), Jinghe Huang (Bethesda, Md.), Leo B. Laub (Richmond), Peter Kwong (Washington, D.C.), Gary Nabel (Cambridge, Mass.), John R. Mascola (Rockville, Md.), Baoshan Zhang (Bethesda, Md.), Rebecca S. Rudicell (Silver Springs, Md.), Ivelin Georgiev (Gaithersburg, Md.), Yongping Yang (Potomac, Md.), Jiang Zhu (Ashburn, Va.), Gilad Ofek (Washington, D.C.)

Assignee:  The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, DC)

Oct. 10, 2017

Rationale-based design of a targeted therapy for cancer

Patent No. 9,782,418

The methods, compositions, and kits of the invention are related to the discovery that lestaurtinib reduces levels and pathway activity of an SPOP substrate. Accordingly, described herein are methods and compositions for the use of lestaurtinib in downregulating one or more SPOP substrates or signaling pathway activities thereof in a subject in need thereof.

Inventors:   Allen J. Lee (Short Hills, N.J.), Jason J. Lee (Short Hills, N.J.), David M. Lu (Richmond), Ruey-Min Lee (Short Hills, N.J.)

Assignee:  Celestra Life Science (Richmond)

Oct. 10, 2017

Bacteriophage and methods of using

Patent No. 9,781,929

Bacteriophage are provided, and methods of making and using the bacteriophage also are provided.

Inventors:  Elisabeth Miller (Chesterfield, Va.), Ujwala Warek (Chester, Va.), Dongmei Xu (Glen Allen, Va.), Fritz Eichenseher (Richmond), Steven Hagens (Richmond), Chengalrayan Kudithipudi (Midlothian, Va.)

Assignee:  Altria Client Services (Richmond) & Micreos BV (Wageningen, Netherlands)

Oct. 10, 2017

Composite material, a ballistic resistant article made from same and method of making the article

Patent No. 9,782,962

A fiber reinforced resin composite for ballistic protection comprising a plurality of first and second plies wherein the first and second plies further comprise a woven fabric and a polymeric resin. The fabric has a Russell tightness factor of from 0.2 to 0.7 and a cover factor of at least 0.45, The fabric is impregnated with the resin, the resin comprising from 5 to 30 weight percent of the total weight of fabric plus resin. The fabric of each first and second ply comprises regions wherein the fabric is distorted from an orthogonal woven state by a distortion angle of least 30 degrees. The composite may further comprising a third ply having a surface area no greater than 50% of the surface area of a first and second ply. The ratio of the number of first plus second plies to the number of third plies is from 2:1 to 12:1.

Inventors:  Jeffrey Alan Hanks (Midlothian, Va.), Brian Charles West (Wilmington, Del.), John Henry McMinn (Newark, Del.), Bryce Vanarsdalen (Cherry Hill, N.J.)

Assignee:  E I Du Pont De Nemours and Co. (Wilmington, Del.)

Oct. 10, 2017

Copolymer fibers and yarns and processes for making same

Patent No. 9,790,622

The present invention concerns methods for obtaining high-tenacity aramid yarn, wherein the yarn is made of a copolymer obtained from a mixture of monomers comprising 5-(6)-amino-2-(p-aminophenyl)benzimidazole, an aromatic para-diamine, and an aromatic para-diacid; the method comprising: a) spinning said copolymer from an inorganic acid solvent to produce the aramid yarn; b) washing said yarn with a basic aqueous solution for at least 5 seconds; and c) heating said yarn; wherein the yarn is heated in at least two process steps, characterized in that (i) in a first step the yarn is heated at a temperature of 200 to 360.degree. C. at a tension of at least 0.2 cN/dtex, followed by (ii) a second step wherein the yarn is heated at a temperature of 370 to 500.degree. C. at a tension of less than 1 cN/dtex. In some embodiments, the yarn has an effective polymer cation to sulfur content molar ratio of at least 0.3. In some embodiments, the yarn has a hydrolytic strength retention of the yarn is greater than 60%.

Inventors:  Warren Francis Knoff (Richmond), Christopher William Newton (Richmond)

Assignee:  E I Du Pont De Nemours and Co. (Wilmington, Del.)

Oct. 17, 2017

Dispensing system and package for use therewith

Patent No. 9,790,013

A system for dispensing articles provided initially in a package is disclosed that comprises a frame configured to support the package of articles and a package-opening tool associated with the frame. The frame includes longitudinally opposed front and rear end sections, and an upper support deck extending at least partially between the front and rear end sections and below which a product display area is provided. The opening tool associated with the frame such that its open the package when the package is moved longitudinally on the upper support deck and relative to the opening tool, thereby allowing the articles to be at least partially dispensed from the package into the product display area.

Inventors:  Caleb S. Loftin (Richmond), Aaron L. Bates (Kennesaw, Ga.), Laurel Thomas (Portland, Ore.), Derek King (Northamptonshire, Britain), John A. Gelardi (Midlothian, Va.)

Assignee:  WestRock MWV (Norcross, Ga.)

Oct. 17, 2017

Recreational swing

Patent No. 9,789,409

A recreational swing having a seating member to support one or more users thereon, and a suspension system that includes one or more bungee cords that permit the base seating portion to be suspended from a suspension point so as to dually function as a swing.

Inventors:  David Yakos (Bozeman, Mont.), Kirk Turner (Bozeman, Mont.), Beverly Fries (Baboursville, Va.), Ting Xu (Richmond)

Assignee:   Plow & Hearth (Madison, Va.)

Oct. 17, 2017

Composite polymer solution of poly(M-phenylene isophthalamide) and copolymer made from 5(6)-amino-2-(P-aminophenyl)benzimidazole

Patent No. 9,790,366

A composite polymer solution comprising a homogeneous mixture of a first polymer solution comprising a first polymer having a structure derived from the reaction of one or more amine monomers and a plurality of acid monomers, wherein i) the one or more amine monomers includes at least 60 mole percent 5(6)-amino-2-(p-aminophenyl)benzimidazole; and ii) the plurality of acid monomers include those having a structure of Cl–CO–Ar.sub.1–CO–Cl and Cl–CO–Ar.sub.2–CO–Cl wherein Ar.sub.1 is a para-oriented aromatic group and Ar.sub.2 is a meta-oriented aromatic group, and wherein the plurality of acid monomers has at least 50 mole percent of the monomer containing Ar.sub.2; and a second polymer solution comprising a second polymer having a structure derived from the reaction of metaphenylene diamine and isophthaloyl chloride.

Inventors:  Kiu-Seung Lee (Midlothian, Va.)

Assignee:  E I Du Pont Nemours and Co. (Wilmington, Del.)

Oct. 17, 2017

Method and apparatus for manufacture of smoking article filter assembly including electrostatically charged fibers

Patent No. 9,788,572

Provided are a method and apparatus for making a cigarette filter assembly for potentially reducing particle breakthrough. The method includes forming a lofty porous network of charge retaining polymer fibers by mechanical, chemical or thermal bonding of the fibers, wrapping the lofty porous network in a cylindrical or tubular shape with optional mediating filter fibers in a filter paper to form a filter plug while maintaining the lofty structure. The charge retaining fibers can be charged to attract and hold particles from such sources as particulate matter from sorbents (preventing break-through), and smoke constituents while having a suitable pressure drop. The apparatus handles the lofty media with minimal crushing, for example, by spacing apart delivery rolls equipped with protrusions to punch, push, and/or pull the lofty media ahead for high speed operation.

Inventors: Szu-Sung Yang (Midlothian, Va.), Lixin L. Xue (Midlothian, Va.), Jing C. Chang (Springfield, Va.)

Assignee:  Philip Morris USA Inc. (Richmond)

Combination treatment of tobacco extract using antioxidants and antioxidant scavengers

Patent No. 9,788,568

A process for treating a tobacco material comprising: (a) extracting a tobacco material with a solvent to produce a tobacco extract and a tobacco residue; (b) contacting the tobacco extract with an antioxidant; and (c) contacting the mixture of (b) with an antioxidant scavenger, to produce a treated tobacco extract. The treated tobacco extract is reapplied to the tobacco residue to form a treated tobacco material. In addition, a smoking composition, a smoking article and a smokeless tobacco oral delivery product contain the treated tobacco material.

Inventors:  Marc Robert Krauss (Midlothian,Va.)

Assignee:  Philip Morris USA Inc. (Richmond)

Oct. 17, 2017

Preventing propagation of malicious content in a virtual universe

Patent No. 9,785,909

An invention for preventing propagation of malicious content within a virtual universe is provided. In one embodiment, a malicious content propagation prevention tool provides this capability. The malicious content propagation prevention tool includes a scanning component configured to scan a plurality of inventory items within a virtual universe. An identification component is configured to identify a set of malicious inventory from the plurality of inventory items. The malicious content propagation prevention tool further comprises an assurance component configured to prevent propagation of malicious content within the virtual universe by performing at least one of the following: isolating the set of malicious inventory items, and modifying a malicious behavior caused by the set of malicious inventory items.

Inventors:  Rick A. Hamilton II (Richmond), Brian M. O’Connell (Research Triangle Park, N.C.), Clifford A. Pickover (Yorktown Heights, N.Y.), Keith R. Walker (Austin, Texas)

Assignee:  International Business Machines Corp. (Armonk, N.Y.)

Oct. 10, 2017

Compositions comprising C5 and C6 oligosaccharides

Patent No. 9,783,860

Compositions comprising C5 and C6 saccharides of varying degrees of polymerization and low levels of undesirable impurities, such as compounds containing sulfur, nitrogen, or metals, are disclosed.

Inventors:  Daniel Clay Floyd (Richmond), Kiran Kadam (Golden, Colo.), Srinivas Kilambi (Duluth, Ga.)

Assignee:  Renmatix Inc. (King of Prussia, Penn.)

Oct. 10, 2017

Mannich detergents for hydrocarbon fuels

Patent No. 9,783,752

New, highly effective substantially pure Mannich detergents for use in hydrocarbon fuels reduce engine deposits in spark and compression ignition internal combustion engines. The Mannich condensation reaction products are obtainable by reacting: (i) a polyamine having primary amino groups, (ii) a hydrocarbyl-substituted hydroxyaromatic compound, and (iii) an aldehyde, wherein the reaction is conducted at in a molar ratio of (i):(ii):(iii) of approximately 1:2:3. The Mannich detergent compounds may be dispersed in a liquid carrier to provide a fuel additive concentrate for hydrocarbon engine fuels which effectively control engine deposit formation in intake valves, port fuel injectors and combustion chambers.

Inventors:  Dennis J. Malfer (Glen Allen, Va.), May D. Thomas (Richmond)

Assignee:  Afton Chemical Corp. (Richmond)

Oct. 10, 2017

Neutralizing GP41 antibodies and their use

Patent No. 9,783,595

Monoclonal neutralizing antibodies are disclosed that specifically bind to the HIV-1 gp41 membrane-proximal external region (MPER). Also disclosed are compositions including the disclosed antibodies that specifically bind gp41, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of HIV-1 in a biological sample, or detecting an HIV-1 infection or diagnosing AIDS in a subject. In additional, the broad neutralization breadth of the disclosed antibodies makes them ideal for treating a subject with an HIV infection. Thus, disclosed are methods of treating and/or preventing HIV infection.

Inventors:  Mark Connors (Bethesda, Md.), Jinghe Huang (Bethesda, Md.), Leo B. Laub (Richmond), Peter Kwong (Washington, D.C.), Gary Nabel (Cambridge, Mass.), John R. Mascola (Rockville, Md.), Baoshan Zhang (Bethesda, Md.), Rebecca S. Rudicell (Silver Springs, Md.), Ivelin Georgiev (Gaithersburg, Md.), Yongping Yang (Potomac, Md.), Jiang Zhu (Ashburn, Va.), Gilad Ofek (Washington, D.C.)

Assignee:  The United States of America, as represented by the Secretary, Department of Health and Human Services (Washington, DC)

Oct. 10, 2017

Rationale-based design of a targeted therapy for cancer

Patent No. 9,782,418

The methods, compositions, and kits of the invention are related to the discovery that lestaurtinib reduces levels and pathway activity of an SPOP substrate. Accordingly, described herein are methods and compositions for the use of lestaurtinib in downregulating one or more SPOP substrates or signaling pathway activities thereof in a subject in need thereof.

Inventors:   Allen J. Lee (Short Hills, N.J.), Jason J. Lee (Short Hills, N.J.), David M. Lu (Richmond), Ruey-Min Lee (Short Hills, N.J.)

Assignee:  Celestra Life Science (Richmond)

Oct. 10, 2017

Bacteriophage and methods of using

Patent No. 9,781,929

Bacteriophage are provided, and methods of making and using the bacteriophage also are provided.

Inventors:  Elisabeth Miller (Chesterfield, Va.), Ujwala Warek (Chester, Va.), Dongmei Xu (Glen Allen, Va.), Fritz Eichenseher (Richmond), Steven Hagens (Richmond), Chengalrayan Kudithipudi (Midlothian, Va.)

Assignee:  Altria Client Services (Richmond) & Micreos BV (Wageningen, Netherlands)

Oct. 10, 2017

Composite material, a ballistic resistant article made from same and method of making the article

Patent No. 9,782,962

A fiber reinforced resin composite for ballistic protection comprising a plurality of first and second plies wherein the first and second plies further comprise a woven fabric and a polymeric resin. The fabric has a Russell tightness factor of from 0.2 to 0.7 and a cover factor of at least 0.45, The fabric is impregnated with the resin, the resin comprising from 5 to 30 weight percent of the total weight of fabric plus resin. The fabric of each first and second ply comprises regions wherein the fabric is distorted from an orthogonal woven state by a distortion angle of least 30 degrees. The composite may further comprising a third ply having a surface area no greater than 50% of the surface area of a first and second ply. The ratio of the number of first plus second plies to the number of third plies is from 2:1 to 12:1.

Inventors:  Jeffrey Alan Hanks (Midlothian, Va.), Brian Charles West (Wilmington, Del.), John Henry McMinn (Newark, Del.), Bryce Vanarsdalen (Cherry Hill, N.J.)

Assignee:  E I Du Pont De Nemours and Co. (Wilmington, Del.)

Oct. 10, 2017

Copolymer fibers and yarns and processes for making same

Patent No. 9,790,622

The present invention concerns methods for obtaining high-tenacity aramid yarn, wherein the yarn is made of a copolymer obtained from a mixture of monomers comprising 5-(6)-amino-2-(p-aminophenyl)benzimidazole, an aromatic para-diamine, and an aromatic para-diacid; the method comprising: a) spinning said copolymer from an inorganic acid solvent to produce the aramid yarn; b) washing said yarn with a basic aqueous solution for at least 5 seconds; and c) heating said yarn; wherein the yarn is heated in at least two process steps, characterized in that (i) in a first step the yarn is heated at a temperature of 200 to 360.degree. C. at a tension of at least 0.2 cN/dtex, followed by (ii) a second step wherein the yarn is heated at a temperature of 370 to 500.degree. C. at a tension of less than 1 cN/dtex. In some embodiments, the yarn has an effective polymer cation to sulfur content molar ratio of at least 0.3. In some embodiments, the yarn has a hydrolytic strength retention of the yarn is greater than 60%.

Inventors:  Warren Francis Knoff (Richmond), Christopher William Newton (Richmond)

Assignee:  E I Du Pont De Nemours and Co. (Wilmington, Del.)

Oct. 17, 2017

Dispensing system and package for use therewith

Patent No. 9,790,013

A system for dispensing articles provided initially in a package is disclosed that comprises a frame configured to support the package of articles and a package-opening tool associated with the frame. The frame includes longitudinally opposed front and rear end sections, and an upper support deck extending at least partially between the front and rear end sections and below which a product display area is provided. The opening tool associated with the frame such that its open the package when the package is moved longitudinally on the upper support deck and relative to the opening tool, thereby allowing the articles to be at least partially dispensed from the package into the product display area.

Inventors:  Caleb S. Loftin (Richmond), Aaron L. Bates (Kennesaw, Ga.), Laurel Thomas (Portland, Ore.), Derek King (Northamptonshire, Britain), John A. Gelardi (Midlothian, Va.)

Assignee:  WestRock MWV (Norcross, Ga.)

Oct. 17, 2017

Recreational swing

Patent No. 9,789,409

A recreational swing having a seating member to support one or more users thereon, and a suspension system that includes one or more bungee cords that permit the base seating portion to be suspended from a suspension point so as to dually function as a swing.

Inventors:  David Yakos (Bozeman, Mont.), Kirk Turner (Bozeman, Mont.), Beverly Fries (Baboursville, Va.), Ting Xu (Richmond)

Assignee:   Plow & Hearth (Madison, Va.)

Oct. 17, 2017

Composite polymer solution of poly(M-phenylene isophthalamide) and copolymer made from 5(6)-amino-2-(P-aminophenyl)benzimidazole

Patent No. 9,790,366

A composite polymer solution comprising a homogeneous mixture of a first polymer solution comprising a first polymer having a structure derived from the reaction of one or more amine monomers and a plurality of acid monomers, wherein i) the one or more amine monomers includes at least 60 mole percent 5(6)-amino-2-(p-aminophenyl)benzimidazole; and ii) the plurality of acid monomers include those having a structure of Cl–CO–Ar.sub.1–CO–Cl and Cl–CO–Ar.sub.2–CO–Cl wherein Ar.sub.1 is a para-oriented aromatic group and Ar.sub.2 is a meta-oriented aromatic group, and wherein the plurality of acid monomers has at least 50 mole percent of the monomer containing Ar.sub.2; and a second polymer solution comprising a second polymer having a structure derived from the reaction of metaphenylene diamine and isophthaloyl chloride.

Inventors:  Kiu-Seung Lee (Midlothian, Va.)

Assignee:  E I Du Pont Nemours and Co. (Wilmington, Del.)

Oct. 17, 2017

Method and apparatus for manufacture of smoking article filter assembly including electrostatically charged fibers

Patent No. 9,788,572

Provided are a method and apparatus for making a cigarette filter assembly for potentially reducing particle breakthrough. The method includes forming a lofty porous network of charge retaining polymer fibers by mechanical, chemical or thermal bonding of the fibers, wrapping the lofty porous network in a cylindrical or tubular shape with optional mediating filter fibers in a filter paper to form a filter plug while maintaining the lofty structure. The charge retaining fibers can be charged to attract and hold particles from such sources as particulate matter from sorbents (preventing break-through), and smoke constituents while having a suitable pressure drop. The apparatus handles the lofty media with minimal crushing, for example, by spacing apart delivery rolls equipped with protrusions to punch, push, and/or pull the lofty media ahead for high speed operation.

Inventors: Szu-Sung Yang (Midlothian, Va.), Lixin L. Xue (Midlothian, Va.), Jing C. Chang (Springfield, Va.)

Assignee:  Philip Morris USA Inc. (Richmond)

Combination treatment of tobacco extract using antioxidants and antioxidant scavengers

Patent No. 9,788,568

A process for treating a tobacco material comprising: (a) extracting a tobacco material with a solvent to produce a tobacco extract and a tobacco residue; (b) contacting the tobacco extract with an antioxidant; and (c) contacting the mixture of (b) with an antioxidant scavenger, to produce a treated tobacco extract. The treated tobacco extract is reapplied to the tobacco residue to form a treated tobacco material. In addition, a smoking composition, a smoking article and a smokeless tobacco oral delivery product contain the treated tobacco material.

Inventors:  Marc Robert Krauss (Midlothian,Va.)

Assignee:  Philip Morris USA Inc. (Richmond)

Oct. 17, 2017

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