The R&D Dept.: Local patents for 10.24.18

Cost-optimized design analysis for rapid microbial prototyping
Patent No. 10,102,335
Computer-implemented methods for providing improvements in genome-scale metabolic models are described. The methods identify and optimize metabolic flux states that minimize the cost of enzyme production while maximizing a desired cellular phenotype. The computer-implemented methods may maximize cellular phenotypes such as growth (biomass) or production of a metabolite, such as a commercially valuable chemical compound, through the selection of metabolic pathways that maximize these phenotypes while minimizing metabolic costs associated with production of the proteomic constituents of individual metabolic pathways. The computer implemented methods may be useful for computationally designing microbial strains for the production of chemicals.
Inventors: Adam Fisher (Richmond), J. Paul Brooks (Richmond), Stephen S. Fong (Mechanicsville, Va.)
Assignee: Virginia Commonwealth University (Richmond)
Oct. 16, 2018

Electronic cigarette
Patent No. 10,098,386
An electronic smoking article includes a liquid supply including liquid material, a heater operable to heat the liquid material to a temperature sufficient to vaporize the liquid material and form an aerosol, a wick in communication with the liquid material and in communication with the heater such that the wick delivers the liquid material to the heater, at least one air inlet operable to deliver air to a central air passage upstream of the heater, and a mouth end insert having at least two diverging outlets.
Inventors: Christopher S. Tucker (Midlothian, Va.), Geoffrey Brandon Jordan (Midlothian, Va.), Barry S. Smith (Hopewell, Va.), Ali A. Rostami (Richmond)
Assignee: Altria Client Services (Richmond)
Oct. 16, 2018

Electronic smoking article
Patent No. 10,098,381
An electronic smoking article includes a heater in communication with a liquid supply reservoir including liquid material and operable to heat the liquid material to a temperature sufficient to volatilize the liquid material contained therein and form an aerosol. The volatilized material flows through a sheath flow and aerosol promoter insert that is operable to cool the aerosol, reduce the particle size of the aerosol and increase the delivery rate of the aerosol.
Inventors: David B. Kane (Richmond), David R. Schiff (Highland Park, N.J.), Chris Carrick (Newark, Del.), Chris Phelan (Collingwood, N.J.), Christopher S. Tucker (Midlothian, Va.)
Assignee: Altria Client Services (Richmond)
Oct. 16, 2018

Removable and reusable protective envelope to display document
Patent No. 10,102,779
A device for displaying a document comprises a front transparent planar sheet and a rear planar sheet, each sheet having three edges that are coterminous with and permanently affixed to a corresponding edge of the other sheet, thereby forming an envelope having three sealed edges and an open end. The device further comprises an adhesive strip affixed to either the front sheet or the rear sheet and positioned across the open end between the front and rear sheets to selectively seal the open end, an interior edge seal positioned interiorly to the three sealed edges, thereby forming a double edge seal along the three sealed edges, and a first corner seal and a second corner seal, each extending onto but not all the way through the adhesive strip on opposite ends of the open end.
Inventors: Joshua Tawes (Smithfield, Va.), Joel Tawes (Chesterfield, Va.), Anthony Stile (Smithfield, Va.), Britt Hawrylak (Fort Worth, Texas), Matthew Hawrylak (Fort Worth, Texas), Ray M. Hawrylak (Fort Worth, Texas), Joseph Cagle (Smithfield, Va.), Benjamin L. Brown (Newport News, Va.)
Assignee: Accelerated Productions Inc. (Smithfield, Va.)
Oct. 16, 2018

Table for performing medical procedures
Patent No. 10,098,590
The table for performing breast biopsies is characterized by features that enhance patient comfort and facilitate performance of the biopsy. An opening in the table allowing the breast to extend below the table top is formed in a removable insert. An area of the insert includes padding. An alternate insert, having a different diameter opening may be selected based on patient breast size. Another insert having an asymmetrical opening may accommodate the patient’s arm when it is desirable to position both the arm and breast of the patient below the table top. The table top is contoured such that symmetrical distal end sections are elevated relative to a central section to support the patient in multiple positions. A removable pad may be placed over the insert. An end portion for padding the hip of the patient is thicker than an end portion for padding the head/neck of the patient.
Inventors: Kenneth F. DeFreitas (Patterson, N.Y.), Ian Shaw (Yorktown Heights, N.Y.), Kathy PIckett (Uncasville, Conn.), Aaron Fand (Bethel, Conn.,), Agnes Mercurio (Longpond, Pa.), Linda Volpe (Narragansett, R.I.), Kelly Farmer (Powhatan, Va.), Darrin Manke (North Andover, Mass.), Erin-Anne A. Lemieux (Milford, N.H.), Christopher Paul Loughnane (Nashua, N.H.), Christopher Laback (Brookline, N.H.)
Assignee: Hologic Inc. (Marlborough, Mass.)
Oct. 16, 2018

Devices, systems and methods for medicament delivery
Patent No. 10,099,023
An apparatus includes a label configured to be coupled to a medicament delivery device. The label includes a first surface and a second surface. The first surface is configured to be coupled to an outer surface of the medicament delivery device. The second surface includes a textual indicia. The label further includes an electronic circuit system configured to output an electronic signal.
Inventors: Eric S. Edwards (Moseley, Va.), Evan T. Edwards (Charlottesville, Va.), Mark J. Licata (Doswell, Va.), Paul F. Meyers (Fishers, Ind.), David A. Weinzierl (Andover, Minn.)
Assignee: kaleo Inc. (Richmond)
Oct. 16, 2018

Infrared scanning port
Patent No. 10,111,351
We disclose a method for securing an infrared transmissive polymer to integrated panels, deadfronts, or transition plates, thus providing a reinforced polymer window through which the thermographer can scan an energized unit without being directly exposed to contact with internal components or having to remove said panels, deadfronts, or transition plates. We also disclose a device for securing the polymer consisting of a retention frame with half shear retainers that keep the polymer locked in place.
Inventors: Brian Raleigh Sullivan (Midolthian, Va.), Michael David VanStavern (Richmond), Kristofor Lynn Redinger (Mechanicsville, Va.), Christopher William Hackman (Henrico, Va.), Richard F. Riczinger (Hanover, Va.)
Assignee: Thomas & Betts International (Wilmington, Del.)
Oct. 23, 2018

3D tracking of an HDR source using a flat panel detector
Patent No. 10,105,554
A method and apparatus are used to compare an intended treatment plan using a radiation source with a delivered plan. This done by arranging markers at known three-dimensional (3D) positions in a detection reference system between a two dimensional radiation detector configured to acquire images generated by radiation emitted by the radiation source and an area where the radiation source is positioned during a treatment. The positions of projections of the markers on an image detected are determined when the radiation source is at a treatment position in an intended treatment plan reference system. A plurality of lines in the detection reference system are calculated, each line being defined by a 3D position of a marker and a 3D position of a corresponding projection of the marker on the detector according to the image. A 3D position of the radiation source in the detection reference system is inferred based on the calculated lines. If no correspondence between the detection reference system and the intended treatment plan reference system is available, the inferred 3D position is matched with the treatment position to extract the correspondence between the detection reference system and the an intended treatment plan reference system. If the correspondence between the detection reference system and the an intended treatment plan reference system is available, the inferred 3D position is compared with the treatment position.
Inventors: Dorin A. Todor (Richmond), Aditya A. Bondal (Madison, WI)
Assignee: Virginia Commonwealth University (Richmond, VA)
Oct. 23, 2018

Dry powder inhaler (DPI) designs for producing aerosols with high fine particle fractions
Patent No. 10,105,500
A dry powder inhaler (DPI) device has a flow passage with a three-dimensional (3D) rod array. The rod array includes multiple rows each having multiple unidirectional rods. The rows are spaced apart along a primary direction of air flow and are staggered. A viewing window to the capsule chamber allows viewing of the capsule’s position within the chamber which provides visual feedback of inhalation flow rate to the user during inhalation. The capsule chamber may orient the capsule parallel to a primary direction of air flow or perpendicular to a primary direction of air flow and provide capsule motion in a plane which is perpendicular to the primary direction of air flow.
Inventors: Phillip Worth Longest (Richmond), Michael Hindle (Richmond), Yoen-Ju Son (Richmond), Srinivas Ravindra Babu Behara (Richmond), Dale Farkas (Richmond)
Assignee: Virginia Commonwealth University (Richmond)
Oct. 23, 2018

Medical injector with compliance tracking and monitoring
Patent No. 10,105,489
A system includes a medicament delivery device and a container configured to receive at least a portion of the medicament delivery device. The medicament delivery device includes an actuator and a first electronic circuit system. The actuator is configured to initiate delivery of a medicament into a body when the actuator is moved from a first position to a second position. The first electronic circuit system is configured to output a first electronic signal when the actuator is moved from the first position to the second position. The container includes a second electronic circuit system configured to receive the first electronic signal. The second electronic circuit system is configured to output a second electronic signal associated with the first electronic signal.
Inventors: Eric S. Edwards (Moseley, Va.), Evan T. Edwards (Charlottesville, Va.), Mark J. Licata (Doswell, Va.), Paul F. Meyers (Fishers, Ind.), David A. Weinzierl (Andover, Minn.), T. Spencer Williamson IV (Richmond)
Assignee: kaleo Inc. (Richmond)
Oct. 23, 2018

Pod assembly, dispensing body, and E-vapor apparatus including the same
Patent No. 10,104,913
An e-vapor apparatus may include a pod assembly and a dispensing body configured to receive the pod assembly. A vaporizer may be disposed in the pod assembly and/or the dispensing body. The pod assembly may include a pre-vapor formulation compartment, a device compartment, and a vapor channel extending from the device compartment and traversing the pre-vapor formulation compartment. The pod assembly is a smart pod configured to receive, store, and transmit information that can be communicated with the dispensing body and/or another electronic device. The proximal portion of the dispensing body includes a vapor passage and a through-hole. The vapor passage may extend from an end surface of the proximal portion to a side wall of the through-hole. The through-hole is configured to receive the pod assembly such that the vapor channel of the pod assembly is aligned with the vapor passage of the dispensing body.
Inventors: Raymond Lau (Richmond), Eric Hawes (Midlothian, Va.), Alistair Bramley (Richmond)
Assignee: Altria Client Services (Richmond)
Oct. 23, 2018

Soluble fiber lozenge
Patent No. 10,105,320
A soluble fiber lozenge provided herein includes a body that is partially or wholly receivable in an oral cavity. The body includes a soluble-fiber matrix and one or more additives dispersed in the soluble-fiber matrix. In some cases, a soluble fiber lozenge provided herein includes at least 40 weight percent of soluble fiber. In some cases, soluble fiber in soluble fiber lozenge provided herein can include maltodextrin. The soluble fiber lozenge is adapted to release one or more additives from the body when the body is received within the oral cavity of a consumer and exposed to saliva. A method of making soluble fiber lozenges provided herein includes forming a molten mixture of at least 40 weight percent soluble fiber, one or more additives, and less than 15 weight percent water while maintaining a mixture temperature of less than 200.degree. C. and portioning the molten mixture into a plurality of soluble fiber lozenges. In some cases, the ingredients can be mixed to form the molten mixture in an extruder.
Inventors: Feng Gao (Midlothian, Va.), Diane L. Gee (Chesterfield, Va.), Shuzhong Zhuang (Glen Allen, Va.), Phillip M. Hulan (Midlothian, Va.), William J. Burke (Nashville, Tenn.), Gerd Kobal (Sandy Hook, Va.)
Assignee: Altria Client Services (Richmond, VA)
Oct. 23, 2018

System and method for providing a group account
Patent No. 10,108,950
Systems and methods include a group fund processor having a communications interface that receives account data associated with a primary account from a device over a network, creates a group fund account, and associate one or more limits with the group fund account based on at least one selection received from the device, an alert interface that transmits an electronic invitation including a description of a first amount to an invited user over the network and receives a response from the invited user to the at least one invitation via the network, wherein the response includes account data associated with a respective group member account of the invited user; and an account processor that links the group fund account to the primary account so that the group fund account may fund the first account, and links respective group member account of the invited user to the group fund account so that the first amount is transferred from the respective group member account of the invited user to the group fund account.
Inventors: Christopher Wetzel (Wayne, Pa.), Daniel Beck (Arlington, Va.), Paul Young Moreton (Glen Allen, Va.)
Assignee: Capital One Services (McLean, Va.)
Oct. 23, 2018

Phosphorus or arsenic ion implantation utilizing enhanced source techniques
Patent No. 10,109,488
Apparatus and method for use of solid dopant phosphorus and arsenic sources and higher order phosphorus or arsenic implant source material are described. In various implementations, solid phosphorus-comprising or arsenic-comprising materials are provided in the ion source chamber for generation of dimer or tetramer implant species. In other implementations, the ion implantation is augmented by use of a reactor for decomposing gaseous phosphorus-comprising or arsenic-comprising materials to form gas phase dimers and tetramers for ion implantation.
Inventors: Oleg Byl (Southbury, Conn.), Sharad N. Yedave (Danbury, Conn.), Joseph D. Sweeney (New Milford, Conn.), Barry Lewis Chambers (Midlothian, Va.), Ying Tang (Brookfield, Conn.)
Assignee: Entegris Inc. (Billerica, Mass.)
Oct. 23, 2018

System and method for automatically authenticating a caller
Patent No. 10,108,966
Systems and methods include an input interface that receives registration information including a contact number input into a mobile device of a user, a call interface that transmits a call signal to a call center system, wherein the call signal comprises the call signal contact number that placed a call associated with the call signal and a communication interface that transmits the registration information to a profile database that stores the registration information as a profile for authenticating the mobile device user and identifying information from the mobile device of the user during the call. The call center system includes a call authentication processor that retrieves the user profile, an authentication interface that receives the identifying information, and an authentication processor that compares the identifying information with the user profile, and routes the call on an authenticated call path if the identifying information at least partially matches the user profile.
Inventors: Christopher D. Martin (Midlothian, Va.)
Assignee: Capital One Services (McLean, Va.)
Oct. 23, 2018

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