The R&D Dept.: Local patents for 12.5.18

System and methods for providing financial account information over a network
Patent No. 10,140,634
A system and method for providing financial account messages to customers while accessing web sites is disclosed. Methods, systems and articles of manufacture consistent with the present invention enable a financial account issuer to provide an application to customer’s computer system over a network. The application may be configured to provide various messages associated with the customer’s financial account provided by the financial account issuer while the customer browses web sites. The financial account messages may be configured to provide interactive and dynamically changing account status information based on attempted purchases of goods and/or services by the customer at merchants’ web sites. The application may also be configured to provide rating information associated with web sites accessed by the customer.
Inventors: Jonathan Turner (Richmond), Arthur Koeppel (Richmond)
Assignee: Capital One Services (McLean, Va.)
Nov. 27, 2018

High speed poucher
Patent No. 10,138,006
An apparatus and methods for producing at extremely high production speeds small pouches filled with tobacco or other granular, powdered or solid content. An endless web substrate, with or without flavor film thereon, is formed into a tubular shape with a longitudinal seam. The tube is cut to individual lengths, and a procession of tubes is crimp-closed at one end, filled and crimp-closed at the other end to complete pouch production. During production, the seams formed at the crimped ends of the pouch are parallel to one another and the longitudinal seam of the pouch is midway between the sides of the pouch and orthogonal to the seams formed at the crimped ends of the pouch.
Inventors: Martin T. Garthaffner (Chesterfield, Va.), Dwight D. Williams (Powatan, Va.), Jeremy J. Straight (Midlothian, Va.), David J. Webb (Jeffersonton, Va.), Carl G. Miller (Richmond)
Assignee: Philip Morris USA Inc. (Richmond)
Nov. 27, 2018

Lawn ornament having fluid and/or wind driven inner and outer frames
Patent No. 10,137,383
A lawn or garden ornament having an inner frame and an outer frame. The outer frame is to receive a fluid such that at least one first orifice arranged therein is to discharge a portion of the fluid in a first direction outwardly therefrom to cause rotation of the outer frame, and at least one second orifice arranged therein is to discharge a portion of the fluid in a second direction inwardly therefrom to contact a surface of inner frame and thereby cause rotation of the inner frame.
Inventors: Paul D. Maguire (Goochland, Va.), Lin C. Gregory (North Chesterfield, Va.), Fei Qiu (Richmond)
Assignee: Plow & Hearth (Madison, Va.)
Nov. 27, 2018

Electronic smoking article
Patent No. 10,136,678
An electronic smoking article includes a liquid supply region including liquid material and a heater-wick element operable to wick liquid material and heat the liquid material to a temperature sufficient to vaporize the liquid material and form an aerosol. The heater-wick element is formed of a carbon or graphite foam.
Inventors: Susan E. Plunkett (Richmond), David B. Kane (Richmond)
Assignee: Altria Client Services (Richmond)
Nov. 27, 2018

Deactivation wipe kit
Patent No. 10,138,448
A hazardous drug deactivation wipe kit includes a first pouch having a one-way valve coupled to an end thereof, a second pouch, and a third pouch. The first pouch contains a wipe saturated in a hypochlorite solution, the second pouch contains a wipe saturated in thiosulfate solution, and the third pouch contains a wipe saturated in isopropyl alcohol solution. The deactivation wipe kit may be used in a clean room to deactivate most hazardous drugs on a work surface.
Inventors: Mark J. Compo (Doylestown, Pa.), Michael Balestri (Mechanicsville, Va.)
Assignee: Veltek Associates Inc. (Malvern, Pa.)
Nov. 27, 2018

System for charting and schedules alongside equipment
Patent No. 10,140,586
A system and approach for charting equipment output values over a historical period of time. A processor may provide the actions for charting, comparison, analysis, detection of the problem, investigation and providing remedial solutions relative to the problem. Charting the values may be done alongside of, for example, an occupancy schedule. If there are not corresponding changes between equipment output values and occupancy, then an investigation may be made to find a problem. If the problem is found, then a correction may be made to solve the problem. The present system and approach for indication of a problem may provide an opportunity to remedy the problem early on thereby resulting in savings of time and costs.
Inventors: John Joseph Frankovich III (Henrico, Va.)
Assignee: Honeywell International Inc. (Morris Plains, N.J.)
Nov. 27, 2018

Electrostatic induction generator for creating high voltage direct current
Patent No. 10,148,198
Systems and methods for generating a high voltage direct current using electric-field generators are disclosed. The electric field generator can comprise a rotor member, rotor poles coupled to the rotor member, stator poles corresponding to the rotor poles, and a dielectric medium positioned between the corresponding stator and rotor poles. The method can comprise applying an electric field between corresponding stator and rotor poles, receiving a mechanical energy input causing the rotor member to rotate, changing an alignment of the corresponding stator and rotor poles as a result of the rotation of the rotor member, increasing the voltage of the electric field between the corresponding stator and rotor poles as a result of the alignment change of the corresponding stator and rotor poles, and discharging the electric field to place a charge on a DC bus when the voltage of the electric field reaches a predetermined level.
Inventors: Weston Clute Johnson (Richmond)
Assignee: Electric Force Motors Inc. (Ashland, Va.)
Dec. 4, 2018

Systems and methods for generating distractors in language learning
Patent No. 10,147,336
Disclosed are systems, methods, and products for language learning software that automatically extracts text from resources using various natural-language processing features, which can be combined with custom-designed learning activities to offer a needs-based, adaptive learning methodology. The system may receive a text, extract keywords pedagogically valuable to non-native language learning, assign a difficulty score to the text using various linguistic attributes of the text, generate a list of potential distractors for each keyword related to a resource to implement in learning activities. Distractors may be of various types, which are dynamically selected from a distractor store depending on a learning activity chosen to meet a learner’s needs. Distractors may vary in difficulty, and may be dynamically selected based on a learner’s overall proficiency or based on a learner’s abilities in specific language skills.
Inventors: Katharine Nielson (Richmond), Kasey Kirkham (New York, N.Y.), Na’im Tyson (Mount Vernon, N.Y.), Andrew Breen (New York, N.Y.)
Assignee: Voxy Inc. (New York, N.Y.)
Dec. 4, 2018

System and method of notifying user near point of sale location of available rewards at the point of sale location
Patent No. 10,147,100
Systems and methods for a point of sale reward system are provided. The system notifies users proximate to a point of sale location of rewards available for redemption specific to that user at that specific point of sale location.
Inventors: Lianghan Chen (Richmond), Kevin Correll (Richmond), Leon Telyaz (Richmond), Nicole E. Pivnick (Richmond)
Assignee: Capital One Financial Corp. (McLean, Va.)
Dec. 4, 2018

Berm and method of manufacturing a berm
Patent No. 10,145,079
A berm comprises fill material having a sloped face portion, a plurality of reinforcing members disposed within the fill material, and an impermeable membrane encapsulating the fill material. The impermeable membrane is impermeable to fluid and comprises a plurality of joined impermeable membrane segments. The sloped face portion is encapsulated by at least a portion of each of two or more of the impermeable membrane segments. Where two impermeable membrane segments encapsulating the sloped face portion meet, an upper end portion of a lower one of the impermeable membrane segments extends into the fill material and a lower end portion of an upper one of the impermeable membrane segments overlaps the lower one of the impermeable membrane segments in a shingled fashion.
Inventors: John Paul Swenson (Glen Allen, Va.), Scott K. Sheridan (Richmond), Carlton Dudding (Glen Allen, Va.)
Assignee: AWT IP (Glen Allen, Va.)
Dec. 4, 2018

Methods for fast nucleic acid amplification
Patent No. 10,144,960
Devices are provided for performing polymerase chain reaction (PCR).
Inventors: Carl T. Wittwer (Salt Lake City, Utah), Jared Steven Farrar (Richmond)
Assignee: University of Utah Research Foundation (Salt Lake City, Utah)
Dec. 4, 2018

Nuclear sulfated oxysterol, potent regulator of lipid homeostasis, for therapy of hypercholesterolemia, hypertriglycerides, fatty liver diseases, and atherosclerosis
Patent No. 10,144,759
The sulfated oxysterol 5-cholesten-3.beta., 25-diol 3-sulphate, a nuclear cholesterol metabolite that decreases lipid biosynthesis and increases cholesterol secretion and degradation, is provided as an agent to lower intracellular and serum cholesterol and/or triglycerides, and to prevent or treat lipid accumulation-associated inflammation and conditions associated with such inflammation. Methods which involve the use of this sulfated oxysterol to treat conditions associated with high cholesterol and/or high triglycerides and/or inflammation (e.g. hypercholesterolemia, hypertriglyceridemia, non-alcoholic fatty liver diseases, atherosclerosis, etc.) are also provided.
Inventors: Shunlin Ren (Richmond), William M. Pandak (Richmond)
Assignee: Virginia Commonwealth University (Richmond)
Dec. 4, 2018

Systems and methods for guiding injections
Patent No. 10,143,809
Systems and methods are described herein for guided injection, which include: one or more controllable light-emitting elements configured to emit non-destructive light and a computing device operably connected to the one or more controllable light-emitting elements configured to emit non-destructive light, the computing device including a processor operable to receive at least one digital representation of a body region of an individual, the body region of the individual including one or more physical registration landmarks, the at least one digital representation including one or more digitally registered injection sites and one or more digital registration landmarks corresponding to the one or more physical registration landmarks on the body region; and control the one or more controllable light-emitting elements to illuminate a location of a surface of the body region of the individual corresponding in location to at least one of the one or more digitally registered injection sites.
Inventors: Edward S. Boyden (Chestnut Hill, Mass.), Hon Wah Chin (Palo Alto, Calif.), Gregory J. Della Rocca (Columbia, Mo.), Daniel Hawkins (Pleasanton, Calif.), Roderick A. Hyde (Redmond, Wash.), Robert Langer (Newton, Mass.), Eric C. Leuthardt (St. Louis, Mo.), Terence Myckatyn (St. Louis, Mo.), Parag Jitendra Parikh (St. Louis, Mo.), Dennis J. Rivet (Richmond), Joshua S. Shimony (St. Louis, Mo.), Michael A. Smith (Phoenix, Ariz.), Elizabeth A. Sweeney (Seattle, Wash.), Clarence T. Tegreene (Mercer Island, Wash.)
Assignee: Elwha (Bellevue, Wash.)
Dec. 4, 2018

E-vaping device having a section with a removable insulator between electrically conductive and passive elements
Patent No. 10,143,240
The section of the e-vaping device includes a power supply configured to send an electrical current to a heater in the e-vaping device, control circuitry configured to cause the power supply to send the electrical current to the heater if the control circuitry senses an air flow, and a removable insulator configured to disrupt an electrical circuit including the power supply, the heater and the control circuitry, a portion of the removable insulator being positioned between electrically conductive and passive components in the electrical circuit.
Inventors: Jarrett Keen (Richmond), Christopher S. Tucker (Midlothian, Va.)
Assignee: Altria Client Services (Richmond)
Dec. 4, 2018

Cartridge and e-vaping device
Patent No. 10,143,239
A cartridge of an e-vaping device includes a housing extending in a longitudinal direction, a reservoir in the housing, a heater in the housing, and an absorbent material at least partially surrounding the sinusoidal shaped member. The reservoir is configured to store a pre-vapor formulation. The heater has a sinusoidal shaped member translating about an elliptical shape to define a channel there through. The absorbent material is in fluid communication with the reservoir.
Inventors:Shmuel Gavrielov (North Miami Beach, Fla.), Yuval Malka (Richmond), Rangaraj S. Sundar (Richmond), Isaac Weigensberg (Richmond), David Rubli (Revava, Israel), Moshe Eliyahu (Beit Shemesh, Israel.), Arye Weigensberg (Modiin, Israel), Christopher S. Tucker (Midlothian, Va.)
Assignee: Altria Client Services (Richmond)
Dec. 4, 2018

Tobacco-free pouched product containing flavor beads providing immediate and long lasting flavor release
Patent No. 10,143,230
A tobacco-free oral pouch product providing immediate and long lasting flavor release comprises a pouch wrapper and tobacco-free flavor beads contained within the pouch wrapper. The flavor beads comprise at least one of microcrystalline cellulose, pectin and sodium alginate, at least one polymer having a higher solubility in saliva than microcrystalline cellulose, pectin and/or sodium alginate, and at least one flavorant. The pectin and sodium alginate are cross-linked. The tobacco-free flavor beads provide immediate release of the flavorant upon placement of a pouch product in a user’s mouth and long lasting release of the flavorant for about 15 minutes to about 80 minutes. The oral pouch product contains only tobacco-free flavor beads.
Inventors: Munmaya K. Mishra (Manakin Sabot, Va.), Biao Duan (Richmond), Daqing Wu (Suwanee, Ga.), William R. Sweeney (Richmond)
Assignee: Philip Morris USA Inc. (Richmond)
Dec. 4, 2018

Poly (meth)acrylate star polymers for lubricant additive applications
Patent No. 10,144,900
The present disclosure relates to star polymers and, in some approaches, star polymers suitable for use as viscosity index improvers in lubricating oil compositions. The present disclosure further relates to oil compositions comprising such polymers. The disclosure also relates to star polymer compositions derived from a sulfur functionalized chain transfer agent core and select (meth)acrylate monomers.
Inventors: Yungwan Kwak (Glen Allen, Va.)
Assignee: Afton Chemical Corp. (Richmond)
Dec. 4, 2018

Data migration using multi-storage volume swap
Patent No. 10,146,453
In one embodiment of the present description, data is migrated to a replacement source storage unit of a storage subsystem while being mirrored from the original source storage unit of a storage subsystem to an original target storage unit of a storage subsystem, and the original source storage unit and the replacement storage unit are swapped in a multi-storage volume swap to write updates to the replacement source storage unit instead of the original source storage unit, in input/output operations issued by at least one host. Further, data stored in the replacement source storage unit, is mirrored from the replacement source storage unit to the original target unit. Other aspects are described.
Inventors: Amy N. Blea (Round Rock, Texas), David R. Blea (Tucson, Ariz.), Gregory E. McBride (Vail, Ariz.), William Rooney (Hopewell Junction, N.Y.), John J. Wolfgang (Midlothian, Va.)
Assignee: International Business Machines Corp. (Armonk, N.Y.)
Dec. 4, 2018

Rotor for vehicle pedal with contacting sensor
Patent No. 10,146,246
A vehicle pedal with a contacting sensor that comprises a pedal arm coupled to and rotatable relative to a pedal housing. A rotor includes a first end coupled to the pedal arm and an opposed end with contactors abutting and adapted to slide against a resistive element in response to the rotation of the pedal arm. A head on the rotor includes means for preventing the over-deflection of the contactors. In one embodiment, the means for preventing the over-deflection of the contactors comprises an extension on the head of the rotor that defines a stop limiting the deflection of the contactors. In another embodiment, the means for preventing the over-deflection of the contactors comprises the combination of a tab on the head of the rotor and a wall in the interior of the pedal housing. The tab abuts against the wall and prevents the movement of the rotor in the direction of the resistive element.
Inventors: Nicholas L. Ladocsi (Midlothian, Va.), Murray Kaijala (Elkhart, Ind.), William S. Stewart (Elkhart, Ind.)
Assignee: CTS Corp. (Lisle, Ill.)
Dec. 4, 2018

Long-range sonar
Patent No. 10,144,138
A long-range sonar assembly for detecting objects approximately 2.5-9.5 meters from a robotic device. The assembly includes a printed circuit board including a local controller operably connected to a processing device and configured to receive instructions from the processing device, a transmit potentiometer operably connected to the local controller and configured to produce a first transmit frequency, and a receive potentiometer operably connected to the local controller and configured to produce a first receive sensitivity; a transducer operably connected to the receive potentiometer; and a flared bell configured to house the transducer and the printed circuit board, the flared bell comprising at least a first enclosure for receiving a sub-assembly comprising the printed circuit board and the transducer.
Inventors: Stephen J. Balas (Midlothian, Va.), Ralph C. McCann III (Williamsburg, Va.)
Assignee: Diversey Inc. (Charlotte, NC)
Dec. 4, 2018

Medicament delivery device for administration of opioid antagonists including formulations for naloxone
Patent No. 10,143,792
Medicament delivery devices for administration of opioid antagonists are described herein. In some embodiments, an apparatus includes a housing, a medicament container disposed within the housing and an energy storage member disposed within the housing. The medicament container is filled with a naloxone composition that includes naloxone or salts thereof, a tonicity-adjusting agent, and a pH adjusting agent, whereby the osmolality of the naloxone composition ranges from about 250-350 mOsm and the pH ranges from about 3-5. The energy storage member is configured to produce a force to deliver the naloxone composition.
Inventors: Eric S. Edwards (Moseley, Va.), Evan T. Edwards (Charlottesville, Va.), Mark J. Licata (Doswell, Va.), Frank E. Blondino (Henrico, Va.)
Assignee: kaleo Inc. (Richmond, Va.)
Dec. 4, 2018

System and methods for providing financial account information over a network
Patent No. 10,140,634
A system and method for providing financial account messages to customers while accessing web sites is disclosed. Methods, systems and articles of manufacture consistent with the present invention enable a financial account issuer to provide an application to customer’s computer system over a network. The application may be configured to provide various messages associated with the customer’s financial account provided by the financial account issuer while the customer browses web sites. The financial account messages may be configured to provide interactive and dynamically changing account status information based on attempted purchases of goods and/or services by the customer at merchants’ web sites. The application may also be configured to provide rating information associated with web sites accessed by the customer.
Inventors: Jonathan Turner (Richmond), Arthur Koeppel (Richmond)
Assignee: Capital One Services (McLean, Va.)
Nov. 27, 2018

High speed poucher
Patent No. 10,138,006
An apparatus and methods for producing at extremely high production speeds small pouches filled with tobacco or other granular, powdered or solid content. An endless web substrate, with or without flavor film thereon, is formed into a tubular shape with a longitudinal seam. The tube is cut to individual lengths, and a procession of tubes is crimp-closed at one end, filled and crimp-closed at the other end to complete pouch production. During production, the seams formed at the crimped ends of the pouch are parallel to one another and the longitudinal seam of the pouch is midway between the sides of the pouch and orthogonal to the seams formed at the crimped ends of the pouch.
Inventors: Martin T. Garthaffner (Chesterfield, Va.), Dwight D. Williams (Powatan, Va.), Jeremy J. Straight (Midlothian, Va.), David J. Webb (Jeffersonton, Va.), Carl G. Miller (Richmond)
Assignee: Philip Morris USA Inc. (Richmond)
Nov. 27, 2018

Lawn ornament having fluid and/or wind driven inner and outer frames
Patent No. 10,137,383
A lawn or garden ornament having an inner frame and an outer frame. The outer frame is to receive a fluid such that at least one first orifice arranged therein is to discharge a portion of the fluid in a first direction outwardly therefrom to cause rotation of the outer frame, and at least one second orifice arranged therein is to discharge a portion of the fluid in a second direction inwardly therefrom to contact a surface of inner frame and thereby cause rotation of the inner frame.
Inventors: Paul D. Maguire (Goochland, Va.), Lin C. Gregory (North Chesterfield, Va.), Fei Qiu (Richmond)
Assignee: Plow & Hearth (Madison, Va.)
Nov. 27, 2018

Electronic smoking article
Patent No. 10,136,678
An electronic smoking article includes a liquid supply region including liquid material and a heater-wick element operable to wick liquid material and heat the liquid material to a temperature sufficient to vaporize the liquid material and form an aerosol. The heater-wick element is formed of a carbon or graphite foam.
Inventors: Susan E. Plunkett (Richmond), David B. Kane (Richmond)
Assignee: Altria Client Services (Richmond)
Nov. 27, 2018

Deactivation wipe kit
Patent No. 10,138,448
A hazardous drug deactivation wipe kit includes a first pouch having a one-way valve coupled to an end thereof, a second pouch, and a third pouch. The first pouch contains a wipe saturated in a hypochlorite solution, the second pouch contains a wipe saturated in thiosulfate solution, and the third pouch contains a wipe saturated in isopropyl alcohol solution. The deactivation wipe kit may be used in a clean room to deactivate most hazardous drugs on a work surface.
Inventors: Mark J. Compo (Doylestown, Pa.), Michael Balestri (Mechanicsville, Va.)
Assignee: Veltek Associates Inc. (Malvern, Pa.)
Nov. 27, 2018

System for charting and schedules alongside equipment
Patent No. 10,140,586
A system and approach for charting equipment output values over a historical period of time. A processor may provide the actions for charting, comparison, analysis, detection of the problem, investigation and providing remedial solutions relative to the problem. Charting the values may be done alongside of, for example, an occupancy schedule. If there are not corresponding changes between equipment output values and occupancy, then an investigation may be made to find a problem. If the problem is found, then a correction may be made to solve the problem. The present system and approach for indication of a problem may provide an opportunity to remedy the problem early on thereby resulting in savings of time and costs.
Inventors: John Joseph Frankovich III (Henrico, Va.)
Assignee: Honeywell International Inc. (Morris Plains, N.J.)
Nov. 27, 2018

Electrostatic induction generator for creating high voltage direct current
Patent No. 10,148,198
Systems and methods for generating a high voltage direct current using electric-field generators are disclosed. The electric field generator can comprise a rotor member, rotor poles coupled to the rotor member, stator poles corresponding to the rotor poles, and a dielectric medium positioned between the corresponding stator and rotor poles. The method can comprise applying an electric field between corresponding stator and rotor poles, receiving a mechanical energy input causing the rotor member to rotate, changing an alignment of the corresponding stator and rotor poles as a result of the rotation of the rotor member, increasing the voltage of the electric field between the corresponding stator and rotor poles as a result of the alignment change of the corresponding stator and rotor poles, and discharging the electric field to place a charge on a DC bus when the voltage of the electric field reaches a predetermined level.
Inventors: Weston Clute Johnson (Richmond)
Assignee: Electric Force Motors Inc. (Ashland, Va.)
Dec. 4, 2018

Systems and methods for generating distractors in language learning
Patent No. 10,147,336
Disclosed are systems, methods, and products for language learning software that automatically extracts text from resources using various natural-language processing features, which can be combined with custom-designed learning activities to offer a needs-based, adaptive learning methodology. The system may receive a text, extract keywords pedagogically valuable to non-native language learning, assign a difficulty score to the text using various linguistic attributes of the text, generate a list of potential distractors for each keyword related to a resource to implement in learning activities. Distractors may be of various types, which are dynamically selected from a distractor store depending on a learning activity chosen to meet a learner’s needs. Distractors may vary in difficulty, and may be dynamically selected based on a learner’s overall proficiency or based on a learner’s abilities in specific language skills.
Inventors: Katharine Nielson (Richmond), Kasey Kirkham (New York, N.Y.), Na’im Tyson (Mount Vernon, N.Y.), Andrew Breen (New York, N.Y.)
Assignee: Voxy Inc. (New York, N.Y.)
Dec. 4, 2018

System and method of notifying user near point of sale location of available rewards at the point of sale location
Patent No. 10,147,100
Systems and methods for a point of sale reward system are provided. The system notifies users proximate to a point of sale location of rewards available for redemption specific to that user at that specific point of sale location.
Inventors: Lianghan Chen (Richmond), Kevin Correll (Richmond), Leon Telyaz (Richmond), Nicole E. Pivnick (Richmond)
Assignee: Capital One Financial Corp. (McLean, Va.)
Dec. 4, 2018

Berm and method of manufacturing a berm
Patent No. 10,145,079
A berm comprises fill material having a sloped face portion, a plurality of reinforcing members disposed within the fill material, and an impermeable membrane encapsulating the fill material. The impermeable membrane is impermeable to fluid and comprises a plurality of joined impermeable membrane segments. The sloped face portion is encapsulated by at least a portion of each of two or more of the impermeable membrane segments. Where two impermeable membrane segments encapsulating the sloped face portion meet, an upper end portion of a lower one of the impermeable membrane segments extends into the fill material and a lower end portion of an upper one of the impermeable membrane segments overlaps the lower one of the impermeable membrane segments in a shingled fashion.
Inventors: John Paul Swenson (Glen Allen, Va.), Scott K. Sheridan (Richmond), Carlton Dudding (Glen Allen, Va.)
Assignee: AWT IP (Glen Allen, Va.)
Dec. 4, 2018

Methods for fast nucleic acid amplification
Patent No. 10,144,960
Devices are provided for performing polymerase chain reaction (PCR).
Inventors: Carl T. Wittwer (Salt Lake City, Utah), Jared Steven Farrar (Richmond)
Assignee: University of Utah Research Foundation (Salt Lake City, Utah)
Dec. 4, 2018

Nuclear sulfated oxysterol, potent regulator of lipid homeostasis, for therapy of hypercholesterolemia, hypertriglycerides, fatty liver diseases, and atherosclerosis
Patent No. 10,144,759
The sulfated oxysterol 5-cholesten-3.beta., 25-diol 3-sulphate, a nuclear cholesterol metabolite that decreases lipid biosynthesis and increases cholesterol secretion and degradation, is provided as an agent to lower intracellular and serum cholesterol and/or triglycerides, and to prevent or treat lipid accumulation-associated inflammation and conditions associated with such inflammation. Methods which involve the use of this sulfated oxysterol to treat conditions associated with high cholesterol and/or high triglycerides and/or inflammation (e.g. hypercholesterolemia, hypertriglyceridemia, non-alcoholic fatty liver diseases, atherosclerosis, etc.) are also provided.
Inventors: Shunlin Ren (Richmond), William M. Pandak (Richmond)
Assignee: Virginia Commonwealth University (Richmond)
Dec. 4, 2018

Systems and methods for guiding injections
Patent No. 10,143,809
Systems and methods are described herein for guided injection, which include: one or more controllable light-emitting elements configured to emit non-destructive light and a computing device operably connected to the one or more controllable light-emitting elements configured to emit non-destructive light, the computing device including a processor operable to receive at least one digital representation of a body region of an individual, the body region of the individual including one or more physical registration landmarks, the at least one digital representation including one or more digitally registered injection sites and one or more digital registration landmarks corresponding to the one or more physical registration landmarks on the body region; and control the one or more controllable light-emitting elements to illuminate a location of a surface of the body region of the individual corresponding in location to at least one of the one or more digitally registered injection sites.
Inventors: Edward S. Boyden (Chestnut Hill, Mass.), Hon Wah Chin (Palo Alto, Calif.), Gregory J. Della Rocca (Columbia, Mo.), Daniel Hawkins (Pleasanton, Calif.), Roderick A. Hyde (Redmond, Wash.), Robert Langer (Newton, Mass.), Eric C. Leuthardt (St. Louis, Mo.), Terence Myckatyn (St. Louis, Mo.), Parag Jitendra Parikh (St. Louis, Mo.), Dennis J. Rivet (Richmond), Joshua S. Shimony (St. Louis, Mo.), Michael A. Smith (Phoenix, Ariz.), Elizabeth A. Sweeney (Seattle, Wash.), Clarence T. Tegreene (Mercer Island, Wash.)
Assignee: Elwha (Bellevue, Wash.)
Dec. 4, 2018

E-vaping device having a section with a removable insulator between electrically conductive and passive elements
Patent No. 10,143,240
The section of the e-vaping device includes a power supply configured to send an electrical current to a heater in the e-vaping device, control circuitry configured to cause the power supply to send the electrical current to the heater if the control circuitry senses an air flow, and a removable insulator configured to disrupt an electrical circuit including the power supply, the heater and the control circuitry, a portion of the removable insulator being positioned between electrically conductive and passive components in the electrical circuit.
Inventors: Jarrett Keen (Richmond), Christopher S. Tucker (Midlothian, Va.)
Assignee: Altria Client Services (Richmond)
Dec. 4, 2018

Cartridge and e-vaping device
Patent No. 10,143,239
A cartridge of an e-vaping device includes a housing extending in a longitudinal direction, a reservoir in the housing, a heater in the housing, and an absorbent material at least partially surrounding the sinusoidal shaped member. The reservoir is configured to store a pre-vapor formulation. The heater has a sinusoidal shaped member translating about an elliptical shape to define a channel there through. The absorbent material is in fluid communication with the reservoir.
Inventors:Shmuel Gavrielov (North Miami Beach, Fla.), Yuval Malka (Richmond), Rangaraj S. Sundar (Richmond), Isaac Weigensberg (Richmond), David Rubli (Revava, Israel), Moshe Eliyahu (Beit Shemesh, Israel.), Arye Weigensberg (Modiin, Israel), Christopher S. Tucker (Midlothian, Va.)
Assignee: Altria Client Services (Richmond)
Dec. 4, 2018

Tobacco-free pouched product containing flavor beads providing immediate and long lasting flavor release
Patent No. 10,143,230
A tobacco-free oral pouch product providing immediate and long lasting flavor release comprises a pouch wrapper and tobacco-free flavor beads contained within the pouch wrapper. The flavor beads comprise at least one of microcrystalline cellulose, pectin and sodium alginate, at least one polymer having a higher solubility in saliva than microcrystalline cellulose, pectin and/or sodium alginate, and at least one flavorant. The pectin and sodium alginate are cross-linked. The tobacco-free flavor beads provide immediate release of the flavorant upon placement of a pouch product in a user’s mouth and long lasting release of the flavorant for about 15 minutes to about 80 minutes. The oral pouch product contains only tobacco-free flavor beads.
Inventors: Munmaya K. Mishra (Manakin Sabot, Va.), Biao Duan (Richmond), Daqing Wu (Suwanee, Ga.), William R. Sweeney (Richmond)
Assignee: Philip Morris USA Inc. (Richmond)
Dec. 4, 2018

Poly (meth)acrylate star polymers for lubricant additive applications
Patent No. 10,144,900
The present disclosure relates to star polymers and, in some approaches, star polymers suitable for use as viscosity index improvers in lubricating oil compositions. The present disclosure further relates to oil compositions comprising such polymers. The disclosure also relates to star polymer compositions derived from a sulfur functionalized chain transfer agent core and select (meth)acrylate monomers.
Inventors: Yungwan Kwak (Glen Allen, Va.)
Assignee: Afton Chemical Corp. (Richmond)
Dec. 4, 2018

Data migration using multi-storage volume swap
Patent No. 10,146,453
In one embodiment of the present description, data is migrated to a replacement source storage unit of a storage subsystem while being mirrored from the original source storage unit of a storage subsystem to an original target storage unit of a storage subsystem, and the original source storage unit and the replacement storage unit are swapped in a multi-storage volume swap to write updates to the replacement source storage unit instead of the original source storage unit, in input/output operations issued by at least one host. Further, data stored in the replacement source storage unit, is mirrored from the replacement source storage unit to the original target unit. Other aspects are described.
Inventors: Amy N. Blea (Round Rock, Texas), David R. Blea (Tucson, Ariz.), Gregory E. McBride (Vail, Ariz.), William Rooney (Hopewell Junction, N.Y.), John J. Wolfgang (Midlothian, Va.)
Assignee: International Business Machines Corp. (Armonk, N.Y.)
Dec. 4, 2018

Rotor for vehicle pedal with contacting sensor
Patent No. 10,146,246
A vehicle pedal with a contacting sensor that comprises a pedal arm coupled to and rotatable relative to a pedal housing. A rotor includes a first end coupled to the pedal arm and an opposed end with contactors abutting and adapted to slide against a resistive element in response to the rotation of the pedal arm. A head on the rotor includes means for preventing the over-deflection of the contactors. In one embodiment, the means for preventing the over-deflection of the contactors comprises an extension on the head of the rotor that defines a stop limiting the deflection of the contactors. In another embodiment, the means for preventing the over-deflection of the contactors comprises the combination of a tab on the head of the rotor and a wall in the interior of the pedal housing. The tab abuts against the wall and prevents the movement of the rotor in the direction of the resistive element.
Inventors: Nicholas L. Ladocsi (Midlothian, Va.), Murray Kaijala (Elkhart, Ind.), William S. Stewart (Elkhart, Ind.)
Assignee: CTS Corp. (Lisle, Ill.)
Dec. 4, 2018

Long-range sonar
Patent No. 10,144,138
A long-range sonar assembly for detecting objects approximately 2.5-9.5 meters from a robotic device. The assembly includes a printed circuit board including a local controller operably connected to a processing device and configured to receive instructions from the processing device, a transmit potentiometer operably connected to the local controller and configured to produce a first transmit frequency, and a receive potentiometer operably connected to the local controller and configured to produce a first receive sensitivity; a transducer operably connected to the receive potentiometer; and a flared bell configured to house the transducer and the printed circuit board, the flared bell comprising at least a first enclosure for receiving a sub-assembly comprising the printed circuit board and the transducer.
Inventors: Stephen J. Balas (Midlothian, Va.), Ralph C. McCann III (Williamsburg, Va.)
Assignee: Diversey Inc. (Charlotte, NC)
Dec. 4, 2018

Medicament delivery device for administration of opioid antagonists including formulations for naloxone
Patent No. 10,143,792
Medicament delivery devices for administration of opioid antagonists are described herein. In some embodiments, an apparatus includes a housing, a medicament container disposed within the housing and an energy storage member disposed within the housing. The medicament container is filled with a naloxone composition that includes naloxone or salts thereof, a tonicity-adjusting agent, and a pH adjusting agent, whereby the osmolality of the naloxone composition ranges from about 250-350 mOsm and the pH ranges from about 3-5. The energy storage member is configured to produce a force to deliver the naloxone composition.
Inventors: Eric S. Edwards (Moseley, Va.), Evan T. Edwards (Charlottesville, Va.), Mark J. Licata (Doswell, Va.), Frank E. Blondino (Henrico, Va.)
Assignee: kaleo Inc. (Richmond, Va.)
Dec. 4, 2018

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