The R&D Dept.: Local patents for 12.11.13

Induction of tumor hypoxia for cancer therapy
Patent 8,591,921
Methods and compositions for enhancing the ability of hypoxia-activated bioreductive agents to kill tumor cells within solid tumors are provided. Local regions of hypoxia are created within a tumor, or within a region containing a tumor, resulting in enhanced activation of hypoxia-activated bioreductive agents (e.g. tirapazamine) within the local region. The activated hypoxia-activated bioreductive agents kill tumor cells in the hypoxic region by catalyzing DNA stand breakage within the tumor cells. Because the activity is localized, side effects that typically occur as a result of systemic administration of bioreductive agents are reduced.
Inventors: Ruey-min Lee (Ambler, Pa.); Peck-sun Lin (Richmond)
Assignee: Virginia Commonwealth University (Richmond)
November 26, 2013

System and method for assigning a line of credit to a credit card account
Patent 8,600,869
A system assigns a credit limit to an account for a credit card of a card holder based on whether the card holder poses an acceptable risk. The system activates an account for the credit card, assigns an initial credit limit well below a tolerance level to the account, develops credit history data based on account activity during predetermined short intervals of time, evaluates the credit history data after each of the predetermined short time intervals, and determines whether to increase the credit limit of the account based on the evaluated credit history.
Inventors: Frank Rotman (Richmond)
Assignee: Capital One Financial Corp. (McLean, Va.)
December 3, 2013

Vertical filter filling machine and process
Patent 8,591,390
A process and apparatus for the mass production of compound cigarette filters function to deposit granular filter material into the open ends of vertically oriented filter tubes. Predetermined amounts of diverse granular material are withdrawn by suction from sources of such material, and these amounts are deposited into the tubes. Solid filter segments seal the granular material within the tube. After one half of each filter tube is filled with granular material and sealed, the tube is inverted and the opposite end is filled in substantially the same manner. When cut in half each filter tube produces two cigarette filters.
Inventors: Steven F. Spiers (Richmond)
Assignee: Philip Morris USA Inc. (Richmond)
November 26, 2013

Container sleeve with container
Patent D694,623
Claims the ornamental design for a container sleeve with container.
Inventors: Stephen J. Bellamah (Midlothian)
Assignee: Altria Client Services Inc. (Richmond)
December 3, 2013

Arc-resistant microwave susceptor assembly
Patent 8,598,500
A susceptor assembly includes electrically conductive vanes configured to prevent arcing in an unloaded microwave oven.
Inventors: Nicole L. Blankenbeckler (Richmond); William R. Corcoran, Jr.; (Kennett Square, Pa.); Dariusz Wlodzimierz Kawka (Midlothian); Mehrdad Mehdizadeh (Avondale, Pa.); Ronald Jack Riegert (Newark, Del.)
Assignee: E I du Pont de Nemours and Company (Wilmington, Del.)
December 3, 2013

Persona-based identity management system
Patent 8,595,857
A method, performed by a computer device, may include receiving personal data from a user device associated with personas, where each of the personas corresponds to at least one classification of requesters, associating the received personal data with at least one of the personas, and identifying any of the classifications that correspond to the personas associated with received personal data. The method may further include receiving, from a data requester, a query including a request for the personal data; associating the data requester with a classification; and comparing the classification associated with the data requester to the classifications associated with personal data. The method may further include sending, to the data requester, a message containing the personal data in response to the classification of the data requester corresponding to the classifications of the personal data.
Inventors: Paul Andrew Donfried (Richmond); Steven T. Archer (Dallas); Guy S. Tallent, Jr.; (New York); Ashley Evans (Stonington, Conn.); Peter S. Tippett (Great Falls, Va.)
Assignee: Verizon Patent and Licensing Inc. (Basking Ridge, N.J.)
November 26, 2013

Arm elevation device for treatment of lymphedema
Patent 8,590,848
An arm elevation device for lymphedema patients suffering from upper limb swelling. The arm elevation device includes a first and a second base, either of which can be selected by the user for elevating the arm in the proper manner depending on the position of the user’s body. A top channel includes a concave and arcuate surface for accommodating the arm of a user. The top channel is straight in order to maintain the arm in a straight orientation and without any bends at the elbow and with minimal bending at the armpit. The arm elevation device includes a foam core surrounded by a fabric cover.
Inventors: Kim Newlen (Richmond)
November 26, 2013

Protective backpack
Patent D694,002
Claims the ornamental design for a protective backpack.
Inventors: Maria Bland (Chesterfield)
November 26, 2013

Tobacco nicotine demethylase genomic clone and uses thereof
Patent 8,592,663
The present invention features tobacco nicotine demethylase nucleic acid and amino acid sequences, tobacco plants and plant components containing such sequences, including tobacco plants and plant components having reduced expression or altered enzymatic activity of nicotine demethylase, methods of use of nicotine demethylase sequences to create plants having altered levels of nornicotine or N’-nitrosonornicotine (“NNN”) or both relative to a control plant, as well as tobacco articles having reduced levels of nornicotine or NNN.
Inventors: Dongmei Xu (Glen Allen)
Assignee: U.S. Smokeless Tobacco Company LLC (Richmond)
November 26, 2013

Hot beverage maker with cup-actuated dispenser
Patent 8,590,445
A hot beverage maker has a stand, fresh water reservoir, a removable tank, and a spring-biased actuator means for dispensing brewed beverages. The tank includes a reservoir portion and the reservoir portion is adapted to hold a brewed liquid so that the tank comprises a fluid bucket when removed from the hot beverage maker. The tank is placed on a platform in a mating relationship so as to engage a warmer plate to keep the contents of the tank warm. The hot beverage maker produces a brewed beverage that is stored in the tank. The dispenser actuator may be engaged by a vessel for holding a hot beverage in order to commence the dispensing of the brewed beverage from the tank.
Inventors: Michael Howard Garman (Midlothian)
Assignee: Hamilton Beach Brands, Inc. (Glen Allen)
November 26, 2013

Roller bearing seal
Patent 8,596,872
A bearing assembly is presented having a novel bearing seal design that, in one embodiment, combines the sealing advantages of both a labyrinth-like seal in combination with a contact seal. The seal is held perpendicularly to the sealing surface, and in one embodiment, substantially divides the sealing forces equally between the lubricant seal portion and the dust seal portion of the seal by virtue of the symmetry of the seal geometry and the application of the resisting force substantially along the seal body’s centerline. The seal departs from the cantilever geometry of prior art seal designs, and in one embodiment, provides an inherently stiffer seal.
Inventors: Jessica Pruden (Richmond)
Assignee: Amsted Rail Company, Inc. (Chicago)
December 3, 2013

System and method for generating a modified web page by inline code insertion in response to an information request from a client computer
Patent 8,601,050
Information requested by a client is intercepted by a network server, which sends the request to the requested information source. The requested information is received and examined by the server to determine if the information is HTML format. If so, the server modifies the requested information by inserting format and request instructions then sends same to the client computer. The client uses the format and request instructions to send a request for supplemental information from a supplemental information source. The associated supplemental information is sent from the supplemental information source to the network client. The format instructions cause the requested information and supplemental information to be displayed in respective first and second display areas.
Inventors: Michael Carringer (Knoxville, Tenn.); Mark Schmid (Midlothian)
December 3, 2013

Isotopically-enriched boron-containing compounds, and methods of making and using same
Patent 8,598,022
An isotopically-enriched, boron-containing compound comprising two or more boron atoms and at least one fluorine atom, wherein at least one of the boron atoms contains a desired isotope of boron in a concentration or ratio greater than a natural abundance concentration or ratio thereof. The compound may have a chemical formula of B.sub.2F.sub.4. Synthesis methods for such compounds, and ion implantation methods using such compounds, are described, as well as storage and dispensing vessels in which the isotopically-enriched, boron-containing compound is advantageously contained for subsequent dispensing use.
Inventors: Robert Kaim. (Brookline, Mass,); Joseph D. Sweeney (Winsted, Conn.); Oleg Byl (Southbury, Conn); Sharad N. Yedave (Danbury, Conn.); Edward E. Jones (Woodbury, Conn.); Peng Zou (Ridgefield, Conn.); Ying Tang (Brookfield, Conn.); Barry Lewis Chambers (Midlothian); Richard S. Ray (New Milford, Conn.)
Assignee: Advanced Technology Materials, Inc. (Danbury, Conn.)
December 3, 2013

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