The former tobacco factory, which has five stories and 140,000 square feet, was converted into offices in 2007.
The Planning Commission recommended that the City Council approve requests by Commonwealth Catholic Charities and Thalhimer Realty Partners.
A pair of West Virginia investors bought it in 2015 for $1 million at a bankruptcy-ordered auction, only to default on the property earlier this year.
The now-vacant property, which has been home to a variety of hospitality concepts, is on the block for the second time in six years.
Golden Nugget and Bally’s are both pursuing the same Southside property, while Wind Creek, the Pamunkey Indian Tribe, Cordish Cos., and Urban One have of sites in mind.
Paper company Manchester Industrial and electronics supplier Strategic Telecom Supply & Solutions currently operate there.
BBQ Chicken and Beer will open in the 3,100-square-foot restaurant space at 3300 W. Cary St., which has seen churn in recent years.
Three of the four proposed sites are on the city’s Southside, while another would be built atop the Movieland complex on Arthur Ashe Boulevard.
Party Perfect is relocating to 26,000 square feet at 2400 Magnolia Ct. in Northside.
The pandemic pivot needs a special use permit from the city but Bow Ties Cinemas expects to operate it from March to November.